Mixed periodontal Th1-Th2 cytokine profile in Actinobacillus actinomycetemcomitans-specific osteoprotegerin ligand (or RANK-L)- mediated alveolar bone destruction in vivo.
نویسنده
چکیده
The Th1/Th2 cytokines involved in human periodontitis remain unclear; therefore, we established a humanized mouse model to investigate this issue in Actinobacillus actinomycetemcomitans-mediated periodontal infection. Quantitative-PCR analysis clearly demonstrates a predominantly mixed Th1 and Th2 expression profile associated with pathogen-specific cell-mediated immunity via osteoprotegerin ligand (or RANK-L)-mediated alveolar bone destruction in vivo.
منابع مشابه
Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 70 9 شماره
صفحات -
تاریخ انتشار 2002